Why undergoing this examination?

Melatonin is a hormone that is synthesized from serotonin, primarily in the pineal gland. The production of melatonin by the pineal gland is stimulated by darkness and inhibited by light, so that it acts as a sleep inducer and is part of the group of signals that regulate the circadian rhythm. The factors that modulate the secretion of melatonin are: environmental (such as lighting, seasons and temperature) and endogenous (such as stress and age). Melatonin has multiple biological functions, one of the most important being the regulation of the sleep/wake cycle.

What is this exam?

The test consists of determining the levels of melatonin in the saliva at different times of the night. Samples are collected by the patient at home and must be delivered to the laboratory the next morning. The analysis allows obtaining the melatonin biorhythm of the patient and to detect any deviation from the normal pattern, both in time and intensity.

For whom is it indicated?

• Individuals with sleep disorders.
• People with rotational changes in working hours who have sleep disorders.
• People with long-term stress, depression, or occupational burnout syndrome.
• Individuals who travel frequently (jet-lag). People who wish to proactively manage their health (especially after 40 years of age).




• Guaranteed from the experience of the Synlab group, the absolute European leader in laboratory diagnosis.
• Objective and detailed results report.

Extra information

DOCUMENTATION – Available on Extranet for clients:
• Informed Consent.
• Clinical Questionnaire.
• Fasting is not necessary for the test.
• Samples of saliva should be collected at the following times: 10:00 p.m. , 2:00 a.m., 4:00 a.m. and 8:00 a.m.

Delivery Time
11 working days
Type of Sample
Saliva collected in specific kit

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