Por que realizar este exame?

Most gastrointestinal cancers are sporadic, but approximately 30% have a familial relationship and about 5-10% are hereditary. The study of genes related to different types of gastrointestinal cancer can determine its hereditary character and prevent its development or detect it in its early stages.

O que é o exame?

The ColonPLUS test consists of analysis of the patient’s DNA by sequencing NGS (Next Generation Sequencing) of 16 genes related to hereditary gastrointestinal cancer and by MLPA (Multiple Ligation Probe Amplification) of APC, EPCAM, MLH1, MSH2, MSH6 and PMS2 genes for the detection of large deletions and duplications.

Para quem é indicado?

Indicated for the following cases:
• Gastrointestinal cancer before the age of 50.
• Multiple cancers in an individual.
• ≥3 members of a family with gastrointestinal cancer and (uterus and ovary).
• ≥10 gastrointestinal polyps throughout life.
• Family history of hereditary colorectal cancer syndromes.
• Patients who wish to know their genetic risk for gastrointestinal cancer.

Tecnologia

Next generation sequencing (NGS) and Multiple Ligation Probe Amplification (MLPA)

Vantagens

SYNLAB GROUP:
• Guaranteed from the experience of the Synlab group, the absolute European leader in laboratory diagnosis. 
COMPREHENSIVE:
Complete genetic study of genes related to hereditary gastrointestinal cancer.
GENETIC COUNSELLING:
• Free genetic counselling available according to each client needs.
BROAD DATABASE:
• The changes found are searched in the most complete and updated databases (Free the data).
RELIABLE:
• Any pathogenic mutation of uncertain significance is confirmed from a new DNA extraction and sequenced again by Sanger which also guarantees 100% coverage of all DNA-readable bases.

Informações Extras

DOCUMENTATION – Available on Extranet for clients:  
• Informed Consent.
• Clinical Questionnaire.
PREPARATION:
• Fasting is not necessary for the test.


Tempo de Entrega
11 working days
Tipo de Amostra
10 mL whole blood in EDTA tube

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