The tumour undergoes genetic modifications over time, producing new mutations in the face of disease progression or even received treatment, generating in some cases resistance to therapy. Knowledge of these mutations allows the use of drugs targeted to a particular tumour at a specific time, thus increasing the rate of treatment success.

The Guardant360 test analyzes 74 genes in a blood sample to identify the presence of point tumor mutations, rearrangements, insertions and deletions (indels), beyond microsatellite instability. The objective of this test is to provide greater assertiveness in directing the patient’s clinical treatment by the analysis of the biological characteristics of the tumor.

Indicated for patients with advanced solid or metastatic tumour in the following cases:
• Progression of the disease with current treatment;
• Inadequate amount of biopsied tissue, unsuitable sample quality for NGS or when biopsy should be obtained from hard-to-reach tissue;
• Biopsy tissue of ≥ 6 months;
• One or more types of therapy or intervention since the last biopsy;
• Sub genotyped patient requiring a more complete test;
• Critical treatment and decision required in 2 weeks or less;
• Patient who prefers a non-invasive assessment of the genetic profile.

Digital sequencing; liquid biopsy