Evaluation of IgE against 112 allergenic proteins
Allergy is a hypersensitivity to a particular substance that when inhaled, ingested or touched produces characteristic symptoms. When an allergen first comes into contact with an allergic subject’s body, the immune system responds by producing a large amount of IgE-like antibodies, through a process called sensitization. Subsequent exposure to the same allergen will produce the release of chemical mediators, in particular histamine, which will produce the characteristic symptoms of the allergic reaction. Allergic reactions can manifest in different ways, and both the symptoms and their intensity may vary depending on each person. The most common symptoms are allergic conjunctivitis, allergic rhinitis, hives and dermatitis, bronchial asthma and anaphylaxis. Therefore, it is important to clarify to which substances the patient is allergic to avoid more serious reactions.
The ISAC Test (Immuno Solid-Phase Allergen Chip) consists of the simultaneous determination of specific IgE antibodies against 112 allergenic proteins present in more than 50 different allergens. The results are classified into four categories: undetectable, low, moderate-high and very high reactions. Alternatively to skin or oral challenge tests, the analysis is performed from a blood sample, avoiding direct exposure of the patient to the allergen.
• Patients poly-sensitized to food, inhalants and/or hymenoptera’s poison.
• Individuals in whom there is no clear correlation between the positivity of conventional allergy tests and the symptoms.
• More complex cases, such as those with an inconsistent clinical history or an unsatisfactory response to treatment.
• Patients with idiopathic anaphylaxis.
• Guaranteed from the experience of the Synlab group, the absolute European leader in laboratory diagnosis.
• Simultaneous analysis of IgEs against 112 allergenic proteins.
• Each allergen is analyzed in triplicate, and the test can be used to detect simultaneously IgE antibodies against: food, plants, animals, insects, molds and synthetic products (eg latex).
• It improves the diagnosis of patients sensitized to food, inhalants and/or hymenoptera.
• Avoids diagnostic errors, especially in patients where there is no clear correlation between the positivity of the conventional allergy tests and the symptoms.
• Prevents therapeutic errors in the composition of allergic vaccines.
• Alternatively to skin or oral challenge tests, the analysis is performed from a blood sample, avoiding direct exposure of the patient to the allergen.
• Fasting is required 4 hours before the exam.