Guardant 360 - Synlab

Guardant 360

Advanced analysis of circulating tumor DNA in the blood

Why undergoing this examination?

Oncological treatment has advanced in recent decades, significantly increasing patient survival rates. This progress is achieved through the development of therapies targeted at the unique characteristics of tumors. Treating such pathologies is particularly delicate and relevant for patients with advanced-stage cancer. For these individuals, whose initial survival rates are low, prospects can improve significantly with specific targeted therapies. Over time, tumors may undergo genetic changes, resulting in new mutations as the disease evolves or in response to received treatment. In certain cases, this can lead to therapy resistance. Therefore, understanding and monitoring these mutations enable the use of drugs targeted to the specific tumor and its specific stage, enhancing the success rate of the treatment. 

What is the exam?

The Guardant360 test allows the identification of the presence of point mutations, rearrangements, insertions, and deletions (ins/del), as well as microsatellite instability in 74 genes from a single blood sample (liquid biopsy). The purpose of the exam is to provide greater accuracy in directing the clinical treatment of the patient by analyzing the unique genetic characteristics of the tumor. 

For whom is it indicated?

The test is recommended for patients with advanced or metastatic solid tumors in the following cases: 

  • Disease progression with the current treatment; 
  • Insufficient quantity of biopsied tissue, inadequate sample quality, or when the biopsy must be obtained from difficult-to-access tissue; 
  • Biopsied tissue from ≥ 6 months ago; 
  • One or more lines of therapy or intervention since the last biopsy; 
  • Subgenotyped patient requiring a more comprehensive test; 
  • Critical treatment decision needed within 2 weeks or less; 
  • Patient prefers a non-invasive assessment of the genetic profile. 


Digital Sequencing 

Guardant 360

Advanced analysis of circulating tumor DNA in the blood




Guaranteed by the experience of the absolute European leader in laboratory diagnostics. 


  • Complete report, including the description of detected mutations as well as the list of available drugs. If no drug is available, clinical trials documented in the literature are presented. 
  • Digital sequencing – analytical specificity of 99.9999%, enhancing NGS performance. 
  • The technology used allows the detection of as low as 0.1% of tumor DNA with alterations. 


Extra Information 


DOCUMENTATION – Available on the SYNLAB Direct for clients 
  • Informed Consent; 
  • Clinical Questionnaire; 
  • Medical Request. 


  • Fasting is not necessary for the test;
  • The test is not recommended for hematologic malignancies, solid tumors in early stages (Stage I-II), and stable disease; 
  • It is advisable for the patient not to undergo the test simultaneously with chemotherapy and radiotherapy. 



Delivery Time 

20 business days 

Sample Type 

20mL of total blood in a special tube provided by Synlab 

Other exams oncology:

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