Why undergoing this examination?

The intestinal permeability refers to the property of the membranes of the intestinal tract to allow the traffic of different macromolecules. Increased intestinal permeability is present in individuals with: allergy and/or food intolerance, celiac disease, intestinal diseases (e.g. Crohn’s disease), and systemic diseases (such as rheumatoid arthritis, ankylosing spondylitis, type 1 diabetes, IgA nephropathy, multiple sclerosis, chronic dermatological pathologies, asthma and various types of cancers). Decreased intestinal permeability can cause malabsorption and lead to malnutrition, even with a normal diet (whether in terms of quality or quantity). The identification of a change in intestinal permeability (whether in excess or lack) allows the therapeutic action in a specific way, with consequent improvement of the symptoms in a high percentage of patients.

What is this exam?

The PI Exam is a noninvasive method that evaluates the integrity and functionality of the intestinal mucosa, which provides assistance in the diagnosis of the causes of a wide variety of intestinal and systemic symptoms, as well as providing information on the therapeutic response and clinical follow-up (activity and prognosis markers). The analysis consists of the administration of non-metabolizable substances of different molecular weights, such as lactulose and mannitol, by oral overload. The quantification by gas chromatography of the percentage of elimination of both substances in the urine informs its absorption.

For whom is it indicated?

• People who wish to actively manage their health.
• People who have any allergies and / or food intolerance.
• Patients with celiac disease or gluten intolerance.
• Patients with chronic intestinal diseases or symptoms.
• Patients with systemic inflammatory or chronic immune diseases.


Gas Chromatography


• Guaranteed from the experience of the Synlab group, the absolute European leader in laboratory diagnosis.
• Objective and detailed results report.
• Step-by-step kit for home collection.

Extra information

DOCUMENTATION – Available on Extranet for clients:
• Informed Consent.
• Clinical Questionnaire.
• Fasting is required 8 hours before the exam.
• Do not take medications or perform activities that require effort.

Delivery Time
15 working days
Type of Sample
10 mL of urine (request the kit with us)

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